CognitiveInvestigational · Research use only
PE-22-28
Synthetic analog of spadin, a TREK-1 channel blocker studied as a rapid-acting antidepressant candidate.
Nootropic
Class
Cognitive / Nootropic
Targets
Loading research profile
Evidence
1 linked resource
Related
Adamax · Dihexa
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Research overview
Benefits
- Antidepressant activity (preclinical)
- Synaptogenesis
- Neuroplasticity
Research side effects
- Research-use only; safety data in healthy humans is limited or absent.
- Headache
- Insomnia if dosed late
- Irritability
- Insomnia
Timing
Typically studied in the morning; avoid late-day dosing if stimulation occurs.
Common research stacks
Semax
Selank
Cerebrolysin
Dihexa
P21
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Trusted research partners
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Studies & resources
Research reference only · Review source material independently · Not medical advice